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Phosphate Binding by Calcium Salts
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Hyperphosphatemia that results from declining kidney function is a hallmark of advanced chronic kidney disease (CKD) and is associated with abnormal mineral and bone metabolism, vascular calcification, and death. Therefore, reducing serum phosphorus levels by binding dietary phosphates in the gastrointestinal tract continues to be a focus of treatment of CKD. 

A Study was Undertaken

This study critically examined the efficacy of phosphate binding by a new phosphate binder, calcium succinate monohydrate (CS), under three in vitro conditions designed to mimic phosphate binding in vivo. Experimental results were compared with phosphate binding by calcium acetate (PhosLo® gelcaps), under the same conditions. 

Description of Experiments

In each experiment a quantity of calcium acetate or calcium succinate equivalent to 169 mg calcium (0.004225 mol) was incubated in 100 mL aqueous buffer solution at 37 °C either with 0.0028 mol phosphate (added as sodium hydrogen phosphate heptahydrate) or with 0.00224 mol phosphate from the same source.

 

Three matrices (0.1 N HCl, pH 1.2; 0.1 N Acetate buffer, pH 4.5; and 0.1 N Borate buffer, pH 6.8) were studied. The solution pH was not adjusted. After sealing tightly with parafilm, the flasks were placed back in the water bath and the timer started. Aliquots (4 mL) were removed from the bulk solution in each flask at 1, 2, 4, and 6 hr and filtered. Portions of the filtrate were quantitatively diluted and analyzed for phosphate using a validated method. 

Summary of Findings

  • At pH 1 (0.1 N HCl), the pH of an empty stomach, calcium does not bind phosphate. 
     

  • At pH 4.5 (0.1 N Acetate Buffer), the pH of a human stomach containing food, approximately 60-65% of the phosphate is bound by calcium succinate or calcium acetate and yields insoluble CaHPO4. 
     

  • At pH 6.8 (0.1 N Borate Buffer), the pH mimicking the changes as food moves from the stomach to the upper intestine (the site of phosphate absorption), phosphate binding by ionized calcium goes to completion, and a mixture of insoluble calcium phosphates is formed. 

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Learn More

Check out our informative resources:

Phosphate Binding Study

This study critically examines the efficacy of phosphate binding. Download our paper here...

Literature Review: Magnesium Inclusion in Phosphate Binding

What may be observed if calcium and magnesium are used in combination?

Download our paper here...

AHA Graphical Abstract

AHA Graphical Abstract - Magnesium Counteracts Vascular Calcification. 

Download the abstract here...

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Phosveda Phosphate Binding

Conclusions for PHOSVEDA®

These data confirm that phosphate binding by calcium succinate is equivalent to that of the Reference Listed Drug, calcium acetate. Therefore, PHOSVEDA (Calcium Succinate) capsules have strong potential as oral phosphate binders for the reduction of serum phosphorus in patients with ESRD. The Active Pharmaceutical Ingredient in PHOSVEDA is calcium (as calcium succinate USP), which is provided as a dry powder in an HPMC capsule. Separate studies show that the capsules dissolve quickly to provide ionized calcium for phosphate binding. Finally, stability studies show that PHOSVEDA capsules are stable for years at room temperature or when exposed to elevated temperatures.

Phosveda Study Results

Phosphate Binding 01:40

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The information and reference materials contained in this document are intended  solely for the general education of the reader. The document is intended to provide  pertinent data to assist you in forming your own conclusions and making decisions. This document should not be considered an endorsement of the information provided nor is it intended for treatment purposes and is not a substitute for professional  evaluation and diagnosis. Additionally, this information is not intended to advocate any indication, dosage or other claim that is not covered, if applicable, in an FDA- approved label.

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